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Rapports / Publications

Rapports d'activités

Publications

  • Madhi, F, C Levy, L Morin, P Minodier, F Dubos, F Zenkhri, MA Dommergues, E Mezgueldi, K Levieux; Pneumonia Study Group, S Béchet, E Varon, R Cohen; GPIP (Pediatric Infectious Disease Group). Change in Bacterial Causes of Community-Acquired Parapneumonic Effusion and Pleural Empyema in Children 6 Years After 13-Valent Pneumococcal Conjugate Vaccine Implementation. J Pediatric Infect Dis Soc. (2018) https://doi.org/10.1093/jpids/piy103.
  • Robineau, O, J Robert, C Rabaud, JP Bedos, E Varon, Y Péan, R Gauzit, et S Alfandari. Management and Outcome of Bloodstream Infections: A Prospective Survey in 121 French Hospitals (SPA-BACT Survey). Infect Drug Resist 11 (2018): 1359‑68.
  • Domenech de Cellès, M, H Arduin, E Varon, C Souty, PY Boëlle, D Lévy-Bruhl, S van der Werf, et al. Characterizing and Comparing the Seasonality of Influenza-Like Illnesses and Invasive Pneumococcal Diseases Using Seasonal Waveforms. Am J Epidemiol 187 (2018): 1029‑39.
  • Hanquet, G, P Krizova, P Valentiner-Branth, SN Ladhani, JP Nuorti, A Lepoutre, J Mereckiene, M Knol, B A Winje, P Ciruela, M Ordobas, M Guevara, E McDonald, E Morfeldt, J Kozakova, HC Slotved, N K Fry, H Rinta-Kokko, E Varon, M Corcoran, A van der Ende, D F Vestrheim, C Munoz-Almagro, P Latasa, J Castilla, A Smith, B Henriques-Normark, R Whittaker, L Pastore Celentano, C Savulescu, on behalf of The SpIDnet/I-MOVE+ Pneumo Group. Effect of Childhood Pneumococcal Conjugate Vaccination on Invasive Disease in Older Adults of 10 European Countries: Implications for Adult Vaccination. Thorax, 2018. https://doi.org/10.1136/thoraxjnl-2018-211767.
  • Bedos, JP, E Varon, R Porcher, P Asfar, Y Le Tulzo, B Megarbane, A Mathonnet, et al. Host-Pathogen Interactions and Prognosis of Critically Ill Immunocompetent Patients with Pneumococcal Pneumonia: The Nationwide Prospective Observational STREPTOGENE Study. Intensive Care Med 44 (2018): 2162 ‑ 73.
  • Ouldali N, Levy C, Varon E, Bonacorsi S, Béchet S, Cohen R, Angoulvant F, French Pediatric Meningitis Network. Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey. Lancet Infect Dis. 2018 Jul 23;
  • Levy C, Vie le Sage F., Varon E., Chalumeau M., Grimprel E., Cohen R. Pediatric Ambulatory and Hospital Networks for Surveillance and Clinical Epidemiology of Community-Acquired Infections. J Pediatr. March 2018, Volume 194, Pages 269–270.e2
  • Rybak A, Levy C, Bonacorsi S, Béchet S, Vié le Sage F, Elbez A, Varon E, Cohen R. Antibiotic Resistance of Potential Otopathogens Isolated From Nasopharyngeal Flora of Children With Acute Otitis Media Before, During and After Pneumococcal Conjugate Vaccines Implementation. Pediatr Infect Dis J. 2018 Mar;37(3):e72-e78.
  • Levy C, Biscardi S, Dommergues MA, Dubos F, Hees L, Levieux K, Aurel M, Minodier P, Zenkhri F, Cohen R; Pneumonia study group. Impact of PCV13 on community-acquired pneumonia by C-reactive protein and procalcitonin levels in children. Vaccine. 2017 Sep 5;35(37):5058-5064. doi: 10.1016/j.vaccine.2017.06.057.
  • Savulescu C, Krizova P, Lepoutre A, Mereckiene J, Vestrheim DF, Ciruela P, Ordobas M, Guevara M, McDonald E, Morfeldt E, Kozakova J, Varon E, Cotter S, Winje BA, Munoz-Almagro C, Garcia L, Castilla J, Smith A, Henriques-Normark B, Celentano LP, Hanquet G; SpIDnet group. Effect of high-valency pneumococcal conjugate vaccines on invasive pneumococcal disease in children in SpIDnet countries: an observational multicentre study. Lancet Respir Med. 2017 Aug;5(8):648-656. doi: 10.1016/S2213-2600(17)30110-8.
  • Arfi A, Cohen R, Varon E, Béchet S, Bonacorsi S, Levy C. Case-control study shows that neonatal pneumococcal meningitis cannot be distinguished from group B Streptococcus cases. Acta Paediatr. 2017 May 16. doi: 10.1111/apa.13919.
  • Hénaff F, Levy C, Cohen R, Picard C, Varon E, Gras Le Guen C, Launay E; French Group of Pediatric Infectious Diseases (GPIP). Risk Factors in Children Older Than 5 Years With Pneumococcal Meningitis: Data From a National Network. Pediatr Infect Dis J. 2017 May;36(5):457-461. doi: 10.1097/INF.0000000000001470.
  • Wintenberger C, Guery B, Bonnet E, Castan B, Cohen R, Diamantis S, Lesprit P, Maulin L, Péan Y, Peju E, Piroth L, Stahl JP, Strady C, Varon E, Vuotto F, Gauzit R; Recommendation Group of the SPILF. Proposal for shorter antibiotic therapies. Med Mal Infect. 2017 Mar;47(2):92-141. doi: 10.1016/j.medmal.2017.01.007.
  • Alari A, Chaussade H, Domenech De Cellès M, Le Fouler L, Varon E, Opatowski L, Guillemot D, Watier L. Impact of pneumococcal conjugate vaccines on pneumococcal meningitis cases in France between 2001 and 2014: a time series analysis. BMC Med. 2016 Dec 21;14(1):211. doi: 10.1186/s12916-016-0755-7.
  • Hays C, Vermee Q, Agathine A, Dupuis A, Varon E, Poyart C, Ploy MC, Raymond J; and the ORP Ile de France Ouest. Demonstration of the herd effect in adults after the implementation of pneumococcal vaccination with PCV13 in children. Eur J Clin Microbiol Infect Dis. 2016 Dec 20. doi: 10.1007/s10096-016-2868-5.
  • Cohen R, Varon E, Béchet S, Bonacorsi S, Levy C. Comparative impact of pneumococcal conjugate vaccines on pneumococcal meningitis according to underlying conditions. Vaccine. 2016 Aug 29. pii: S0264-410X(16)30765-4.
  • Le Bourgeois M, Ferroni A, Leruez-Ville M, Varon E, Thumerelle C, Brémont F, Fayon MJ, Delacourt C, Ligier C, Watier L, Guillemot D; Children, Antibiotics, Nonsteroidal Anti-inflammatory Drugs and Childhood Empyema (ChANCE) Study Group. Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study. J Pediatr. 2016 Aug;175:47-53.e3.
  • Janoir C, Lepoutre A, Gutmann L, Varon E. Insight Into Resistance Phenotypes of Emergent Non 13-valent Pneumococcal Conjugate Vaccine Type Pneumococci Isolated From Invasive Disease After 13-valent Pneumococcal Conjugate Vaccine Implementation in France. Open Forum Infect Dis. 2016 Feb 2;3(1):ofw020.
  • Lepoutre A, Ploy M, Gaillat J, Forestier E, Sifaoui F, Guinard J, Janssen C, Tellini C, Lévy-Bruhl D, Varon E. Épidémiologie des infections invasives à pneumocoque de l'adulte en France et recommandations vaccinales, résultat de la cohorte Surveillance des infections invasives à pneumocoques (SIIP) de l'adulte. Med Mal Infect. 2016 Jun;46(4 Suppl 1):3.
  • Gaillat J, Varon E, Lanotte P, Lepoutre A, Pelloux I, Epaulard O, Bernard L, Chavanet P, Mootien Y. Surveillance épidémiologique clinico-microbiologique des infections invasives à pneumocoque de l'adulte (SIIPA). Med Mal Infect. 2016 Jun;46(4 Suppl 1):3.
  • Varon, E ; Cohen, R ; Béchet, S ; Doit, C ; Levy, C , Invasive disease potential of pneumococci before and after the 13-valent pneumococcal conjugate vaccine implementation in children., Vaccine, 2015 Nov 17;33(46):6178-85. doi: 10.1016/j.vaccine.2015.10.015.
  • Chidiac, C , SPILF working group, Update on a proper use of systemic fluoroquinolones in adult patients (ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, pefloxacin)., Med Mal Infect, 2015, 45 : 348-73.
  • Pulcini C ; Alfandari S ; Ballereau F ; Bonnet E ; Bruneel F ; Castan B et al. , [European Antibiotic Awareness Day: What is new in France?]., Med Mal Infect, 2015, 45 : 345-7.
  • Cohen R ; Varon E ; Doit C ; Schlemmer C ; Romain O ; Thollot et al. , A 13-year survey of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 and PCV13 implementation., Vaccine, 2015, 33 : 5118-26.
  • Levy, C ; Varon, E ; Béchet, S ; Cohen, R , Does the 13-valent pneumococcal conjugate vaccine have an impact on pneumococcal meningitis in children?, Clin. Infect. Dis., 2015 ,11 pii: civ692. [Epub ahead of print].
  • Chapoutot AG ; Dessein R ; Guilluy O ; Lagrée M ; Wallet F ; Varon E et al. , Impact of the 13-valent pneumococcal conjugate vaccine on the incidence of pneumococcal meningitis in children., Epidemiol. Infect., 2015, 1-5 [Epub ahead of print]
  • Godot C ; Levy C ; Varon E ; Picard C ; Madhi F ; Cohen R et al. , Pneumococcal Meningitis Vaccine Breakthroughs and Failures After Routine 7-Valent and 13-Valent Pneumococcal Conjugate Vaccination in Children in France., Pediatr. Infect. Dis. J., 2015, 34, e260-3 .
  • Angoulvant F ; Cohen R ; Doit C ; Elbez A ; Werner A ; Béchet S et al. , Trends in antibiotic resistance of Streptococcus pneumoniae and Haemophilus influenzae isolated from nasopharyngeal flora in children with acute otitis media in France before and after 13 valent pneumococcal conjugate vaccine introduction., BMC Infect. Dis., 2015, 15, 236 doi: 10.1186/s12879-015-0978-9.
  • de Cellès M D ; Pons-Salort M ; Varon E ; Vibet MA ; Ligier C ; Letort V et al. , Interaction of Vaccination and Reduction of Antibiotic Use Drives Unexpected Increase of Pneumococcal Meningitis., Sci Rep, 2015, 5, 11293.
  • Maury, E ; Tankovic, J ; Pichereau, C ; Varon, E ; Guidet, B , Immunochromatographic test of pneumococcal antigen performed on cerebrospinal fluid for pneumococcal pneumoniae., Med Mal Infect, 2015, 45, 237-8
  • Kempf M ; Varon E ; Lepoutre A ; Gravet A ; Baraduc R ; Brun M et al. , Decline in antibiotic resistance and changes in the serotype distribution of Streptococcus pneumoniae isolates from children with acute otitis media; a 2001-2011 survey by the French Pneumococcal Network., Clin. Microbiol. Infect., 2015, 21, 35-42
  • Lepoutre A ; Varon E ; Georges S ; Dorléans F ; Janoir C ; Gutmann L et al. , Impact of the pneumococcal conjugate vaccines on invasive pneumococcal disease in France, 2001-2012., Vaccine, 2015, 33, 359-66
  • Mizrahi A ; Cohen R ; Varon E ; Bonacorsi S ; Bechet S ; Poyart C et al. , Non typable-Haemophilus influenzae biofilm formation and acute otitis media., BMC Infect. Dis., 2014, 14, 400
  • Levy C ; Varon E ; Picard C ; Béchet S ; Martinot A ; Bonacorsi S et al. , Trends of pneumococcal meningitis in children after introduction of the 13-valent pneumococcal conjugate vaccine in France., Pediatr. Infect. Dis. J., 2014, 33, 1216-21
  • Levy C ; Varon E ; Taha MK ; Béchet S ; Bonacorsi S ; Cohen R et al. , [Changes in bacterial meningitis in French children resulting from vaccination]., Arch Pediatr, 2014, 21, 736-44
  • Hurmic O ; Grall N ; Al Nakib M ; Poyart C ; Grondin S ; Ploy MC et al. , Evidence of a clonal expansion of Streptococcus pneumoniae serotype 19A in adults as in children assessed by the DiversiLab® system., Eur. J. Clin. Microbiol. Infect. Dis., 2014, 33, 2067-73
  • Gaschignard J ; Levy C ; Chrabieh M ; Boisson B ; Bost-Bru C ; Dauger S et al. , Invasive pneumococcal disease in children can reveal a primary immunodeficiency., Clin. Infect. Dis., 2014, 59, 244-51
  • Janoir C, Cohen R, Levy C, Bingen E, Lepoutre A, Gutmann L, Varon E; Observatoires Régionaux du Pneumocoque (ORP) network. PLoS One. 2014 Mar 6;9(3):e90935. eCollection 2014.
  • Angoulvant F, Levy C, Grimprel E, Varon E, Lorrot M, Biscardi S, Minodier P, Dommergues MA, Hees L, Gillet Y, Craiu I, Zenkhri F, Dubos F, Guen CG, Launay E, Martinot A, Cohen R. Clin Infect Dis. 2014 Apr;58(7):918-24. Epub 2014 Feb 13.
  • Feikin DR, Kagucia EW, Loo JD, Link-Gelles R, Puhan MA, Cherian T, Levine OS, Whitney CG, O'Brien KL, Moore MR; Serotype Replacement Study Group. Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction: a pooled analysis of multiple surveillance sites. PLoS Med. 2013;10(9):e1001517.
  • Caeymaex L, Varon E, Levy C, Béchet S, Derkx V, Desvignes V, Doit C, Cohen R. Characteristics and outcomes of acute otitis media in children carrying Streptococcus pneumoniae or Haemophilus influenzae in their nasopharynx as a single otopathogen after introduction of the heptavalent pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2013 Nov 20. [Epub ahead of print].
  • Opatowski L, Varon E, Dupont C, Temime L, van der Werf S, Gutmann L, Boëlle PY, Watier L, Guillemot D. Assessing pneumococcal meningitis association with viral respiratory infections and antibiotics: insights from statistical and mathematical models. Proc Biol Sci. 2013 Jun 19;280(1764):20130519.
  • Cohen R, Martin E, de La Rocque F, Thollot F, Pecquet S, Werner A, Boucherat M, Varon E, Bingen E, Levy C. Probiotics and Prebiotics in Preventing Episodes of Acute Otitis Media in High-Risk Children: A Randomized, Double-Blind, Placebo-Controlled Study. Pediatr Infect Dis J. 2013 Feb 20.
  • Munier AL, de Lastours V, Varon E, Donay JL, Porcher R, Molina JM. Invasive pneumococcal disease in HIV-infected adults in France from 2000 to 2011: antimicrobial susceptibility and implication of serotypes for vaccination. Infection. 2013 Jun;41(3):663-8.
  • Carlet J, Rambaud C, Pulcini C; l'Alliance contre développement des bactéries multirésistantes (ACdeBMR). [Alliance against MDRO: safeguarding antibiotics]. Ann Fr Anesth Reanim. 2012 Sep;31(9):704-8.
  • Cohen R, Levy C, Bingen E, Bechet S, Derkx V, Werner A, Koskas M, Varon E. Nasopharyngeal carriage of children 6 to 60 months during the implementation of the 13-valent pneumococcal conjugate vaccine. Arch Pediatr. 2012 Oct;19(10):1132-9.
  • Varon E. Epidemiology of Streptococcus pneumoniae. Med Mal Infect. 2012 Aug;42(8):361-5.
  • Grohs P, Trieu-Cuot P, Podglajen I, Grondin S, Firon A, Poyart C, Varon E, Gutmann L. Molecular basis for different levels of tet(M) expression in Streptococcus pneumoniae clinical isolates. Antimicrob Agents Chemother. 2012 Oct;56(10):5040-5.
  • Cohen R, Bingen E, Levy C, Thollot F, Boucherat M, Derkx V, Varon E. Nasopharyngeal flora in children with acute otitis media before and after implementation of 7 valent pneumococcal conjugate vaccine in France. BMC Infect Dis. 2012 Mar 7;12:52.
  • Cohen R, Levy C, Bingen E, Koskas M, Nave I, Varon E. Impact of 13-valent pneumococcal conjugate vaccine on pneumococcal nasopharyngeal carriage in children with acute otitis media. Pediatr Infect Dis J. 2012 Mar;31(3):297-301.
  • Couloigner V, Levy C, François M, Bidet P, Hausdorff WP, Pascal T, Boucherat M, Bingen E, Mariani P, Pierrot S, Bille E, Carbonnelle E, Varon E, Cohen R. Pathogens implicated in acute otitis media failures after 7-valent pneumococcal conjugate vaccine implementation in France: distribution, serotypes, and resistance levels. Pediatr Infect Dis J. 2012 Feb;31(2):154-8.
  • Levy C, Varon E, Bingen E, Aujard Y, Boucherat M, Cohen R et le Groupe des pédiatres et microbiologistes de l'Observatoire National des Méningites. Épidémiologie nouvelle des méningites bactériennes sous l'effet des vaccinations. Arch Pediatr. 2011 ;18:91-93.
  • Domenech de Cellès M, Opatowski L, Salomon J, Varon E, Carbon C, Boëlle PY, Guillemot D. Intrinsic epidemicity of Streptococcus pneumoniae depends on strain serotype and antibiotic susceptibility pattern. Antimicrob Agents Chemother. 2011 Nov;55(11):5255-61.
  • Grohs P, Janoir C, Grondin S, Simon S, Bonnet G, Henry L, Gutmann L, Varon E. Accuracy of MIC determination for Streptococcus pneumoniae using the Sirscan2000automatic MIC determination system. Diagn Microbiol Infect Dis. 2011 Jul;70(3):399-403.
  • Cohen R, Bingen E, Levy C, Benani M, Thollot F, Klink Z, Schlemmer C, Elbez A, Varon E. Antibiotic resistance of pneumococci and H. influenzae isolated from the nasopharyngeal flora of children with acute otitis media between 2006 and 2010. Arch Pediatr. 2011 Aug;18(8):926-31.
  • Cohen R, Levy C, Bonnet E, Thollot F, Boucherat M, Fritzell B, Derkx V, Bingen E, Varon E. Risk factors for serotype 19A carriage after introduction of 7-valent pneumococcal vaccination. BMC Infect Dis. 2011 Apr 18;11:95.
  • Grall N, Hurmic O, Al Nakib M, Longo M, Poyart C, Ploy MC, Varon E, Raymond J; ORP Ile de France Ouest. Epidemiology of Streptococcus pneumoniae in France before introduction of the PCV-13 vaccine. Eur J Clin Microbiol Infect Dis. 2011 Dec;30(12):1511-9.
  • Chavanet P, Atale A, Mahy S, Neuwirth C, Varon E, Dabernat H, Portier H. Nasopharyngeal carriage, antibiotic susceptibility and serotyping of Streptococcus pneumoniae and Haemophilus influenzae in children attending day care centers. Med Mal Infect. 2011 Jun;41(6):307-17.
  • Levy C, Varon E, Bingen E, Lécuyer A, Boucherat M, Cohen R; Bacterial Meningitis Study Group. PneumococcaL meningitis in french children before and after the introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2011 Feb;30(2):168-70.
  • Kempf M, Baraduc R, Bonnabau H, Brun M, Chabanon G, Chardon H, Croizé J, Demachy MC, Donnio PY, Dupont P, Fosse T, Gibel L, Gravet A, Grignon B, Hadou T, Hamdad F, Joly-Guillou ML, Koeck JL, Maugein J, Péchinot A, Ploy MC, Raymond J, Ros A, Roussel-Delvallez M, Segonds C, Vergnaud M, Vernet-Garnier V, Lepoutre A, Gutmann L, Varon E, Lanotte P. Epidemiology and antimicrobial resistance of Streptococcus pneumoniae in France in 2007: data from the pneumococcus surveillance network. Microb Drug Resist. 2011 Mar;17(1):31-6.
  • Hanquet G, Kissling E, Fenoll A, George R, Lepoutre A, Lernout T, Tarragó D, Varon E, Verhaegen J. Pneumococcal serotypes in children in 4 European countries. Emerg Infect Dis. 2010 Sep;16(9):1428-39.
  • Loulergue P, Burgel PR, Carrat F, Fritzell B, Guthmann JP, Locht C, Power UF, Varon E, Dusser D, Launay O. Report of the 2nd "French Clinical Vaccinology Meeting Jean-Gerard Guillet": immunization and respiratory diseases. Vaccine. 2010 Sep 14;28(40):6551-5.
  • Alexandre C, Dubos F, Courouble C, Pruvost I, Varon E; Hospital Network for Evaluating the Management of Common Childhood Diseases, Martinot A. Rebound in the incidence of pneumococcal meningitis in northern France: effect of serotype replacement. Acta Paediatr. 2010 Nov;99(11):1686-90.
  • Hanquet G, Perrocheau A, Kissling E, Bruhl DL, Tarragó D, Stuart J, Stefanoff P, Heuberger S, Kriz P, Vergison A, de Greeff SC, Amato-Gauci A, Celentano LP; ECDC Country Experts for Pneumococcal Disease. Surveillance of invasive pneumococcal disease in 30 EU countries: Towards a European system? Vaccine. 2010 May 21;28(23):3920-8.
  • Varon E, Mainardi JL, Gutmann L. Streptococcus pneumoniae: still a major pathogen. Clin Microbiol Infect. 2010 May;16(5):401.
  • Opatowski L, Mandel J, Varon E, Boëlle PY, Temime L, Guillemot D. Antibiotic dose impact on resistance selection in the community: a mathematical model of beta-lactams and Streptococcus pneumoniae dynamics. Antimicrob Agents Chemother. 2010 Jun;54(6):2330-7.
  • Doit C, Mariani-Kurkdjian P, Mahjoub-Messai F, Bidet P, Bonacorsi S, Carol A, Varon E, Bingen E. Epidemiology of pediatric community-acquired bloodstream infections in a children hospital in Paris, France, 2001 to 2008. Diagn Microbiol Infect Dis. 2010 Mar;66(3):332-5.
  • Matta M, Kernéis S, Day N, Lescat M, Buu Hoi A, Varon E, Gutmann L, Mainardi JL. Do clinicians consider the results of the BinaxNOW Streptococcus pneumoniae urinary antigen test when adapting antibiotic regimens for pneumonia patients? Clin Microbiol Infect. 2010 Sep;16(9):1389-93.
  • Cohen R, Levy C, Bonnet E, Grondin S, Desvignes V, Lecuyer A, Fritzell B, Varon E. Dynamic of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 introduction in France. Vaccine. 2010 Aug 23;28(37):6114-21.
  • Debbache K, Varon E, Hicheri Y, Legrand P, Donay JL, Ribaud P, Cordonnier C. The epidemiology of invasive Streptococcus pneumoniae infections in onco-haematology and haematopoietic stem cell transplant patients in France. Are the serotypes covered by the available anti-pneumococcal vaccines? Clin Microbiol Infect. 2009 Sep;15(9):865-8.
  • Varon E. [Epidemiology of acute bacterial meningitis in adult patients in France]. Med Mal Infect. Med Mal Infect. 2009 Jul-Aug;39(7-8):432-44.
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